World Families Forums - DYS464 in R1b

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Author Topic: DYS464 in R1b  (Read 1169 times)
wing_genealogist
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« on: April 15, 2013, 10:33:40 AM »

DYS464 is a multi-copy marker, most typically seen four times in individuals. For most clades, DYS464 is located near a SNP which has a g allele near each of the four locations. However, somewhere under R1b a SNP mutation occurred where a g allele mutated to a c allele. For most R1b individuals, they have three of the mutated c alleles and one unmutated g allele.

Because this c to g SNP is located in a Palindromic arm, it is subject to recLOH mutations (which somehow changed the original gggc mutation to a cccg modal values), and due to the frequency of this type of mutation it is not placed in the Y-SNP tree. While we cannot purchase a SNP test to see this c/g SNP, it is available for purchase as an Advanced Order STR test: 464x.

Has there ever been any study undertaken to examine when the original gggc mutation occurred and why it quickly mutated to cccg? I am particularly interested in the timing of this mutation in relationship to the timing of the P25 mutation, which also occurred within one of the Palindromic arms.
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Y-DNA - R1b M157.2 (a private/family subclade of Z6/Z352) 111 markers tested

mt-DNA - J1c2g with the following private mutations: 315.1C 522.1A 522.2C C9974T C16256T (FMS tested and submitted to GenBank)

Autosomal - shows as a typical English ancestry. Tested with 23andMe, FTDNA
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