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Author Topic: U5, 150T and longevity?  (Read 1633 times)
byakhee_2001
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« on: February 19, 2008, 10:19:17 AM »

U5 and 150T polymorphism seems to be associated with longevity.

Here is the article:

http://dienekes.blogspot.com/2004/10/mtdna-and-longevity.html

http://www.nature.com/ejhg/journal/v13/n2/full/5201308a.html
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Stacy
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« Reply #1 on: February 28, 2008, 07:01:31 PM »

Longevity runs in my maternal line and I have a U5a1a Haplogroup.
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byakhee_2001
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« Reply #2 on: February 29, 2008, 05:36:54 AM »

Do you have 150T mutation?

You need to do HVR2 test. HVR1 doesn't detect this mutation.
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Kivinen
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« Reply #3 on: June 06, 2008, 02:32:56 PM »

I read that as well.

I too am U5 (U5b2) and have 150T.  Longevity is true on my mtdna side for sure.  My grandmother lived to just a few weeks shy of 99.  Her maternal aunts lived into their 90's as well.

HVR1 Haplogroup   U5b2

HVR1 differences
from CRS
   16192T
    16311C

HVR2 differences
from CRS
   73G
    150T
    249-
    263G
    309.1C
    315.1C
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I1*-AS, Kittler = DYS385a/b = 14/13 Hi/Lo [AS modality]. M170+ M253+ M258+ M307+ P19+ P30+ P38+ M161- M21- M223- M227- M26- M72- P109- P259- P37.2- Find me at 23andMe; I'm L22- [rs34626372 A] "ancestral". 
U5b2 with FGS and GenBank published, with an exact FGS match.
100% Ethnic Finn 500+ years.
Diana Sotela
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« Reply #4 on: February 07, 2012, 01:58:21 PM »

I have the 150T

Most women in my family have led long lives.  Grandma was 88 when she passed and all of her sister were the same or older.  Coincidently my grandmother was a vegetarian, wouldn't eat meat.


    16192T
    16218T
    16270T
    16320T

   
HVR2 DIFFERENCES FROM rCRS

    73G
    150T
    263G
    315.1C
    523.1C
    523.2A

the study you referenced also says this so it's sort of confusing?

"Our data thus showed that 150T is associated with longevity in subhaplogroups J2, D5 and M7b that harbour 10398G and 489C, but not in subhaplogroups T2, U5 and N9a that lack the latter two polymorphisms. The association between a combination of these three mtDNA variants and longevity provides the first epidemiological support for the assumption that the pathogenic or adaptive nature of a variant is influenced by interactions with other loci in mtDNA.19"


« Last Edit: February 07, 2012, 02:03:20 PM by Diana » Logged

MT DNA- u5b1d1
Paternal DNA- R1b1a2a1a1b R-P312-DF27+
Paternal MT DNA- A2j

Maternal Ancestor- Agnes Barnard, Leicestershire England 1535-1609
Paternal Ancestor- Mateo de Sotelo Guillen, Valladolid, Spain 1594
Paternal Maternal Ancestor- Maria Palacios Perez, Costa Rica
Maliclavelli
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« Reply #5 on: February 07, 2012, 03:09:27 PM »

   16192T
    16218T
    16270T
    16320T

   
HVR2 DIFFERENCES FROM rCRS

    73G
    150T
    263G
    315.1C
    523.1C
    523.2A
It would be interesting an FGS: you could be an U5b*, but it needs the coding region.
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Maliclavelli


YDNA: R-S12460


MtDNA: K1a1b1e

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