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Author Topic: DYS464 curiosities  (Read 1596 times)
Alpine
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« on: November 16, 2012, 03:16:40 PM »

I have been told that since I have DYS464 of 11-11-11-11 that this means I am from haplogroups T , I2a1 or I2b1. Since I am the only one in T that has this marker what does this say?

I now it is a fast mutating markers and its presented order is unknown, but does it indicate any timeframe in reflect of age.
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YDna = T1a2b (L446)
MtDNA = H2a1c (haplofind)

wing_genealogist
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« Reply #1 on: November 16, 2012, 05:36:33 PM »

DYS464 is a multi-copy marker (that is, there are multiple copies of this same STR located within the Y-Chromosome). Besides the "regular" mutations to each STR marker (ie up or down), multi-copy markers also can mutate in a different way, where 1 copy of the marker overwrites another copy (called a RecLoH). In addition, the number of DYS464 markers a person has can change as another type of mutation (where a whole STR marker is either deleted or copied sometimes called an In/Del).

Given the fact all 4 of your DYS markers are 11, it is almost certain this was either a RecLoH or a deletion.  There is a special test, 464x, which can better tell you which of these events occurred.
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Y-DNA - R1b M157.2 (a private/family subclade of Z6/Z352) 111 markers tested

mt-DNA - J1c2g with the following private mutations: 315.1C 522.1A 522.2C C9974T C16256T (FMS tested and submitted to GenBank)

Autosomal - shows as a typical English ancestry. Tested with 23andMe, FTDNA
Alpine
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« Reply #2 on: November 17, 2012, 09:16:57 PM »

DYS464 is a multi-copy marker (that is, there are multiple copies of this same STR located within the Y-Chromosome). Besides the "regular" mutations to each STR marker (ie up or down), multi-copy markers also can mutate in a different way, where 1 copy of the marker overwrites another copy (called a RecLoH). In addition, the number of DYS464 markers a person has can change as another type of mutation (where a whole STR marker is either deleted or copied sometimes called an In/Del).

Given the fact all 4 of your DYS markers are 11, it is almost certain this was either a RecLoH or a deletion.  There is a special test, 464x, which can better tell you which of these events occurred.

I thought the test was only for R1b-U106 people as this occurs 99% for them.

Does this 464 mutate in only one direction i.e up or down? and does it have any indication of age of marker?
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YDna = T1a2b (L446)
MtDNA = H2a1c (haplofind)

wing_genealogist
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« Reply #3 on: November 17, 2012, 09:54:58 PM »

While the 464x test is typically used by R1b folks, it can also be used in cases like yours, where your unusual results indicate something occurred.

As with any other marker, 464 can mutate in either direction, but as the number of repeats grow, it appears it does slightly affect the mutation rate (as most of the mutations in 464 occur at the c & d markers)
Logged

Y-DNA - R1b M157.2 (a private/family subclade of Z6/Z352) 111 markers tested

mt-DNA - J1c2g with the following private mutations: 315.1C 522.1A 522.2C C9974T C16256T (FMS tested and submitted to GenBank)

Autosomal - shows as a typical English ancestry. Tested with 23andMe, FTDNA
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