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Author Topic: HVR1 and HVR2 differences  (Read 1813 times)
Alpine
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« on: October 31, 2012, 01:47:32 AM »

what are these supposed to represent from FTDNA


HVR1 DIFFERENCES FROM RSRS

    A16129G
    T16187C
    C16189T
    T16223C
    G16230A
    T16278C
    C16311T



HVR2 DIFFERENCES FROM RSRS

    G73A
    C146T
    C152T
    C195T
    A247G
    315.1C
    522.1A
    522.2C

   
Are they a form of mutation?
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YDna = T1a2b (L446)
MtDNA = H2a1c (haplofind)

Maliclavelli
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« Reply #1 on: October 31, 2012, 06:49:50 AM »

Alpine, RSRS is the reassessment of the mtDNA haplotree done by Behar 2012b et alii. It doesn’t take more as reference the r[evised]C[ambridge]R[eference]S[equence] but the origin of our haplotree. This does mean that what is a mutation in RSRS often wasn’t in rCRS. But they are the same.
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Maliclavelli


YDNA: R-S12460


MtDNA: K1a1b1e

Alpine
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« Reply #2 on: November 01, 2012, 01:30:57 AM »

Alpine, RSRS is the reassessment of the mtDNA haplotree done by Behar 2012b et alii. It doesn’t take more as reference the r[evised]C[ambridge]R[eference]S[equence] but the origin of our haplotree. This does mean that what is a mutation in RSRS often wasn’t in rCRS. But they are the same.

Ok, but if you take me for example, remove my 16519C mutation which does not count for anything as per this scientific world , ( note: only 55% of H have it ). Remove my other mutation 315.1C for similar issues and what do I have left is 263G.......this mutation only takes me out of CRS.
FTDNA for me used 7028C to place me in H ,then with this theory and since I have 4769A it will/should make me H2a.
In RSRS there are 2 markers for me which are K, C16311T and X, T16223C which say I am not a pure "clan-mother" H mtDna person, but have mutated into H overtime..........Would these old K and X markers indicate my previous Mtdna. If so
Then the system we have in place in only viewing mutations to clarify someboby MtDna is clearly "incomplete".

And if a mutation into H is correct, then H is only numerous in Europe due to mutations into H overtime and RSRS should be the only course to indicate somebody marker
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YDna = T1a2b (L446)
MtDNA = H2a1c (haplofind)

Maliclavelli
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« Reply #3 on: November 01, 2012, 10:38:55 AM »

Alpine, Genetics is not “Mela Melinda” (translated for not Italian speaking people: “Mela Melinda” is a product of Trentino, Genetics is a worldwide science).
You have said that “my only mutations are 16519C, 263G and 315.1C”.These are your mutations as for rCRS and this is the same as to say that for RSRS your mutations are

HVR1 DIFFERENCES FROM RSRS

    A16129G
    T16187C
    C16189T
    T16223C
    G16230A
    T16278C
    C16311T



HVR2 DIFFERENCES FROM RSRS

    G73A
    C146T
    C152T
    C195T
    A247G
    315.1C
    522.1A
    522.2C

How do you know that in the coding region you have the mutations “7028C to place me in H […] and since I have 4769A”? Of course, being you hg. H, you have 7028C (which isn’t transcribed) and 4769A is the mutation of H2a, but who did test you for these SNPs if you have been tested only for HVRI and II?
   
“In RSRS there are 2 markers for me which are K, C16311T and X, T16223C”. Hg. K, which is mine and comes from a different pathway, from U and not from R0, has T16311C, and T16223C is the ancestral one and isn’t a mutation in rCRS.

What you write after is a nonsense. You are hg. H, perhaps H2a (who knows?), and if you want to know your subclade you have only to do an FGS or at least 23andMe, which, even though tests only 2500 SNPs out of 16569, tests many SNPs in the coding region and may suggest the subclade you belong.
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Maliclavelli


YDNA: R-S12460


MtDNA: K1a1b1e

Alpine
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Posts: 35


« Reply #4 on: November 02, 2012, 01:48:43 AM »

Alpine, Genetics is not “Mela Melinda” (translated for not Italian speaking people: “Mela Melinda” is a product of Trentino, Genetics is a worldwide science).
You have said that “my only mutations are 16519C, 263G and 315.1C”.These are your mutations as for rCRS and this is the same as to say that for RSRS your mutations are

HVR1 DIFFERENCES FROM RSRS

    A16129G
    T16187C
    C16189T
    T16223C
    G16230A
    T16278C
    C16311T



HVR2 DIFFERENCES FROM RSRS

    G73A
    C146T
    C152T
    C195T
    A247G
    315.1C
    522.1A
    522.2C

How do you know that in the coding region you have the mutations “7028C to place me in H […] and since I have 4769A”? Of course, being you hg. H, you have 7028C (which isn’t transcribed) and 4769A is the mutation of H2a, but who did test you for these SNPs if you have been tested only for HVRI and II?
   
“In RSRS there are 2 markers for me which are K, C16311T and X, T16223C”. Hg. K, which is mine and comes from a different pathway, from U and not from R0, has T16311C, and T16223C is the ancestral one and isn’t a mutation in rCRS.

What you write after is a nonsense. You are hg. H, perhaps H2a (who knows?), and if you want to know your subclade you have only to do an FGS or at least 23andMe, which, even though tests only 2500 SNPs out of 16569, tests many SNPs in the coding region and may suggest the subclade you belong.

I do not know what your first 2 lines mean/refer too. There is no nationality, religion or language when talking about genetics, they are irrelevant, these things for me go into the toilet and are flushed.

There are other ways to get CR results, many systems and tools.......but lets get back to the basics, FTDNA had to give me a marker so they searched my CR and found 7028, so they gave me H
other markers I have are
4769G
750A
8860A
15326A
152T
16291C
6632C
14305G
11140C  and another 15 or so

According to SNPedia, I classify for H, H2, H2a2a and not H2a2 or H2a1 ( I am using mtdna tree v15 ) . FTDNA has no option but saying I am H until I do the FMS test and they will then say H2a........if they say H2a2a then there system lacks a degree of integrity and also leads to bottlenecks in the H2a2a line.

I will eventually most propably do a FMA test once my H2 project people write to me.
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YDna = T1a2b (L446)
MtDNA = H2a1c (haplofind)

Maliclavelli
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Posts: 2158


« Reply #5 on: November 02, 2012, 03:37:36 AM »

There are other ways to get CR results, many systems and tools.......but lets get back to the basics, FTDNA had to give me a marker so they searched my CR and found 7028, so they gave me H
other markers I have are
4769G
750A
8860A
15326A
152T
16291C
6632C
14305G
11140C  and another 15 or so

According to SNPedia, I classify for H, H2, H2a2a and not H2a2 or H2a1 ( I am using mtdna tree v15 ) . FTDNA has no option but saying I am H until I do the FMS test and they will then say H2a........if they say H2a2a then there system lacks a degree of integrity and also leads to bottlenecks in the H2a2a line.

I will eventually most propably do a FMA test once my H2 project people write to me.


Alpine, if you have these data, you have had an FGS/FMS. It won't be difficult to know your subclade. But the other 15 or so which are? Are they the RSRS? They must be taken separated.
But perhaps if you send me your results from FTDNA, I could say something more carefull.
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Maliclavelli


YDNA: R-S12460


MtDNA: K1a1b1e

Alpine
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Posts: 35


« Reply #6 on: November 02, 2012, 02:27:42 PM »

There are other ways to get CR results, many systems and tools.......but lets get back to the basics, FTDNA had to give me a marker so they searched my CR and found 7028, so they gave me H
other markers I have are
4769G
750A
8860A
15326A
152T
16291C
6632C
14305G
11140C  and another 15 or so

According to SNPedia, I classify for H, H2, H2a2a and not H2a2 or H2a1 ( I am using mtdna tree v15 ) . FTDNA has no option but saying I am H until I do the FMS test and they will then say H2a........if they say H2a2a then there system lacks a degree of integrity and also leads to bottlenecks in the H2a2a line.

I will eventually most propably do a FMA test once my H2 project people write to me.


Alpine, if you have these data, you have had an FGS/FMS. It won't be difficult to know your subclade. But the other 15 or so which are? Are they the RSRS? They must be taken separated.
But perhaps if you send me your results from FTDNA, I could say something more carefull.

these are all the CR markers I have so far......not in any order
152T
750A
4080T
8634T
4769A
6632T
9299A
8860A
6716A
16172T
15314G
11140C
16293A
13708G
14305G
16291C
15326A
16051A
« Last Edit: November 02, 2012, 02:28:27 PM by Alpine » Logged

YDna = T1a2b (L446)
MtDNA = H2a1c (haplofind)

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