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Author Topic: Question about chip-based SNP testing  (Read 690 times)
wing_genealogist
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« on: August 04, 2012, 08:28:32 AM »

Could some SNPs be placed on a chip which cannot be found via Sanger testing? Or is it necessary for there to be (basically the same) primers which are needed for Sanger testing to develop each individual probe for the chip?

I'm wondering (out loud) if there may end up some SNPs on the Nat Geno 2.0 chip which FT-DNA cannot make available (due to primer-related issues)
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Y-DNA - R1b M157.2 (a private/family subclade of Z6/Z352) 111 markers tested

mt-DNA - J1c2g with the following private mutations: 315.1C 522.1A 522.2C C9974T C16256T (FMS tested and submitted to GenBank)

Autosomal - shows as a typical English ancestry. Tested with 23andMe, FTDNA
vineviz
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« Reply #1 on: August 04, 2012, 09:40:10 AM »

Could some SNPs be placed on a chip which cannot be found via Sanger testing? Or is it necessary for there to be (basically the same) primers which are needed for Sanger testing to develop each individual probe for the chip?

I'm wondering (out loud) if there may end up some SNPs on the Nat Geno 2.0 chip which FT-DNA cannot make available (due to primer-related issues)

Yes, assay chips can  and do include SNPs that won't work in Sanger testing.
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wing_genealogist
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« Reply #2 on: August 04, 2012, 10:07:38 AM »

It'll definitely be interesting to see what SNPs appear in the Nat Geno 2.0 chip. Here's to hoping a good bunch of SNPs still unavailable from FT-DNA do show up!!
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Y-DNA - R1b M157.2 (a private/family subclade of Z6/Z352) 111 markers tested

mt-DNA - J1c2g with the following private mutations: 315.1C 522.1A 522.2C C9974T C16256T (FMS tested and submitted to GenBank)

Autosomal - shows as a typical English ancestry. Tested with 23andMe, FTDNA
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